| 175096 | O17514 | MES2_CAEEL | Histone-lysine N-methyltransferase mes-2 (EC 2.1.1.356) (E(z) homolog) (Maternal-effect sterile protein 2) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown results in extended lifespan in wild type worms and in a glp-1(e2141) mutant background which lacks a germline (PubMed:22212395). Also leads to reduced H3K27me3 levels on metaphase chromosomes (PubMed:26904949). Double RNAi-mediated knockdown together with mes-6 RNAi results in ectopic expression of the homeobox protein egl-5 in the head region (PubMed:17574230). This ectopic expression of egl-5 in the head region is enhanced in a nfya-1 bp4 mutant background (PubMed:17574230). In addition in this background in males, there is ectopic expression of egl-5 in the mid-body region including in seam cells and hypodermal nuclei, and there is ectopic ray formation (PubMed:17574230). {ECO:0000269|PubMed:17574230, ECO:0000269|PubMed:22212395, ECO:0000269|PubMed:26904949}. |