| 175126 | Q06561 | UNC52_CAEEL | Basement membrane proteoglycan (Perlecan homolog) (Uncoordinated protein 52) (Protein unc-52) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown in L4 larval stage, causes a small increase in ectopic membrane extensions from body wall muscles (PubMed:16495308). RNAi-mediated knockdown causes an accumulation in the proximal gonad of endomitotic mature oocytes in 30 percent of animals (PubMed:17326220). RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation, and disrupted integrin attachment complexes in muscle (PubMed:22253611). This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization (PubMed:22253611). RNAi-mediated knockdown reduces lifespan (PubMed:36173858). {ECO:0000269|PubMed:16495308, ECO:0000269|PubMed:17326220, ECO:0000269|PubMed:22253611, ECO:0000269|PubMed:36173858}. |