| 175404 | Q9TZ64 | KLF1_CAEEL | Kruppel-like factor 1 | DISRUPTION PHENOTYPE | RNAi-mediated knockown leads to increased cell death, perhaps by apoptosis, in the germline and uterus of hermaphrodites (PubMed:18680432). Lipid contents in the intestine increase (PubMed:18680432). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:24805825). Abolishes lifespan extension completely on an eat-2 mutant background, independent of whether knockdown is ubiquitous, or targeted only to the intestine (PubMed:24805825). Abolishes lifespan extension on either isp-1;ctb-1 double mutant, or isp-1, gas-1 or mev-1 single mutant backgrounds; knockdown is most effective when applied in early adulthood, rather than during early development (PubMed:31346165). Further decreases the lower movement rates of isp-1;ctb-1 double mutants (PubMed:31346165). {ECO:0000269|PubMed:18680432, ECO:0000269|PubMed:24805825, ECO:0000269|PubMed:31346165}. |