| 175545 | P39745 | MPK1_CAEEL | Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP kinase sur-1) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes an increase in the number of germline cells in the mitotic zone, a lack of transition zone and a defect in pachytene progression resulting in a proximal gonad devoid of nuclei (PubMed:19826475, PubMed:16319922). Causes sterility (PubMed:19826475). RNAi-mediated knockdown in adults decreases lifespan (PubMed:20624915). RNAi-mediated knockdown of isoform b in lip-1 and puf-8 double mutant causes a decrease in number of germline tumors (PubMed:22820175). RNAi-mediated knockdown causes a reduction in intestinal ilys-3 expression in response to M.nematophilum-mediated bacterial infection (PubMed:27525822). {ECO:0000269|PubMed:16319922, ECO:0000269|PubMed:19826475, ECO:0000269|PubMed:20624915, ECO:0000269|PubMed:22820175, ECO:0000269|PubMed:27525822}. |