| 175603 | Q20060 | SMC4_CAEEL | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown disrupts prometaphase chromosome organization and chromosome segregation in mitosis and meiosis II and leads to aneuploidy throughout development (PubMed:11914278, PubMed:23684975). Disrupts mix-1 localization to mitotic chromosomes (PubMed:11914278). Increased levels of phosphorylated air-2 at the spindle midzone, indicating activation of the abscission checkpoint (PubMed:23684975). Results in cleavage furrow regression and failed cytokinesis during the first and second embryonic divisions (PubMed:23684975). {ECO:0000269|PubMed:11914278, ECO:0000269|PubMed:23684975}. |