| 175662 | Q18221 | SET2_CAEEL | Histone-lysine N-methyltransferase set-2 (EC 2.1.1.-) (SET domain-containing protein 2) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown results in disruption of invariant Y-to-PDA transdifferentiation (PubMed:25124442). Results in decreased trimethylation at 'Lys-4' of histone H3 (PubMed:20555324). Leads to an extension of lifespan (PubMed:20555324). Leads to a deregulation of fat metabolism and to an enrichment of mono-unsaturated fatty acids (PubMed:28379943). {ECO:0000269|PubMed:20555324, ECO:0000269|PubMed:25124442, ECO:0000269|PubMed:28379943}. |