| 175667 | Q18223 | FBSP1_CAEEL | F-box/SPRY domain-containing protein 1 (F-box synaptic protein 1) | DISRUPTION PHENOTYPE | Synaptic defects that include both overdevelopment and underdevelopment of presynaptic and postsynaptic termini (PubMed:15208641). Abnormal morphology of cholinergic and GABAergic neuromuscular junctions (NMJs) characterized by uneven distribution of presynaptic markers snb-1 and unc-17 and post-synaptic markers GABA receptor unc-49 and AChR unc-38. Also, formation of abnormally large and small synapses (PubMed:23665919). Frequency of spontaneous miniature synaptic release (mPSC) from cholinergic and GABAergic NMJs is reduced (PubMed:23665919). In a daf-2 e1370 mutant background, but not in a daf-2 e1370 and daf-16 mu86 mutant background, the morphology of NMJs is normal and normal synaptic transmission is partially restored (PubMed:23665919). Nuclear translocation of daf-16 (isoform a) is impaired in muscles but not in the intestine (PubMed:23665919). {ECO:0000269|PubMed:15208641, ECO:0000269|PubMed:23665919}. |