| 175804 | Q09967 | EGG1_CAEEL | LDL receptor repeat-containing protein egg-1 (Egg sterile protein 1) | DISRUPTION PHENOTYPE | Temperature sensitive phenotype with severe sterility at the restrictive temperature of 25 degrees Celsius (PubMed:16360684, PubMed:20971008). Zygotes exit the spermatheca with a pinched morphology and leave a trailing section behind and are polyspermic (PubMed:20971008). The eggshell chitin layer is fragmented and often accumulates at one end of the embryo (PubMed:20971008). Ovulation is severely reduced resulting in oocyte accumulation in the gonad and a disappearance of sperm in the spermatheca (PubMed:16360684). Conversely, although sperm and oocyte appear to make contact in the spermatheca no visible fertilization occurs and endomitotic oocytes accumulate with age (PubMed:16360684). Male fertility is not affected (PubMed:16360684). Simultaneous RNAi-mediated knockdown with egg-2 results in complete sterility (PubMed:16360684). In unfertilized oocytes, disrupts the homogenous distribution of cortical chitin synthase chs-1, pseudophosphatase egg-3 and kinase mbk-2 (PubMed:20971008). {ECO:0000269|PubMed:16360684, ECO:0000269|PubMed:20971008}. |