| 175862 | P46549 | SULU_CAEEL | Serine/threonine-protein kinase SULU (EC 2.7.11.1) (Protein kinase 18) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown leads to embryonic lethality (PubMed:23064028). Increased and prolonged cortical contractility leading to a more persistent pseudocleavage in surviving embryos (PubMed:23064028). Decrease in rho-1 anterior cortex localization and increase in posterior cortex localization, leading to a loss of asymmetric rho-1 cortex localization during early embryonic cell division (PubMed:23064028). Increased cortical nmy-2 network between the foci, suggesting that the enhanced contractions are due to increased actomyosin contractility (PubMed:23064028). Reduction in the size of the anterior cortex and increase in the size of the posterior cortex during polarity establishment in the early embryo (PubMed:23064028). Leads to a delay in embryonic cell cycle progression (PubMed:23064028). Double RNAi-mediated knockdown with rho-1 results in loss of cortical contractility (PubMed:23064028). {ECO:0000269|PubMed:23064028}. |