| 175893 | Q09388 | ACM2_CAEEL | Muscarinic acetylcholine receptor gar-2 (G-protein-linked acetylcholine receptor 2) | DISRUPTION PHENOTYPE | Egg-laying defect whereby 30% of eggs are laid at an early developmental stage (PubMed:12954868). Increased sensitivity to the acetylcholine esterase inhibitor Aldicarb, which results in accelerated paralysis likely due to enhanced acetylcholine release by ventral cord neurons and enhanced depolarization of muscles on one side of the body (PubMed:18614679). Exploratory behavior is similar to wild-type, but in contrast to wild-type, there is irregular locomotory behavior characterized by a 9.2% increase in speed of locomotion over a 1-minute interval, decreased turning frequency, reduced rate of reversals, and a 25% increase in the maximal distance covered over a 40 second interval (PubMed:18614679). Double knockout with the G-protein coupled receptor for GABA subunit gbb-2 results in a slight increase in sensitivity to Aldicarb and accelerated paralysis 50 minutes following exposure to Aldicarb as compared to the gar-2 and gbb-2 single mutants (PubMed:18614679). {ECO:0000269|PubMed:12954868, ECO:0000269|PubMed:18614679}. |