| 175918 | Q22795 | SET1_CAEEL | Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361) | DISRUPTION PHENOTYPE | Mutant animals lack methylation of 'Lys-20' of histone H4 (H4K20me) (PubMed:23028348). In a glp-1(e2141) mutant background which lacks a germline, the X-linked genes aco-1, ajm-1 and apl-1 are up-regulated (PubMed:23028348). RNAi-mediated knockdown leads to embryonic lethality in a mutant background of the dosage compensation proteins dpy-21 or dpy-28 (PubMed:23028348). Increases 'Lys-16' acetylation of histone H4 on hermaphrodite X chromosomes (PubMed:22393255). In the TOR complex 2 mutant background rict-1, suppresses the growth delay and elevated body fat index (PubMed:23884442). Causes mitotic chromosome segregation defects and chromosome bridges resulting in delayed or arrested embryonic development and embryonic lethality (PubMed:28867287). {ECO:0000269|PubMed:22393255, ECO:0000269|PubMed:23028348, ECO:0000269|PubMed:23884442, ECO:0000269|PubMed:28867287}. |