| 176122 | P34308 | CAN_CAEEL | Calpain clp-1 (EC 3.4.22.-) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown results in adult muscle defects which include irregularities in sarcomeric structures, disorganized integrin attachment complexes, and increased mitochondrial fragmentation (PubMed:22253611). RNAi-mediated knockdown in integrin attachment complex component mutants unc-112 (e669su250) and unc-52 (r367) blocks the protein degradation which normally results from complex disruption (PubMed:22253611). RNAi-mediated knockdown suppresses cell death in the neurodegenerative models deg-3 (u662), gsa-1 (Q227L) and mec-4 (u231) (PubMed:12410314). {ECO:0000269|PubMed:12410314, ECO:0000269|PubMed:22253611}. |