Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:176179
  • Symbol:unc-116
  • Description:Kinesin heavy chain
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Gene ID Entry Entry Name Protein Name Type Information
176179 P34540 KINH_CAEEL Kinesin heavy chain (Uncoordinated protein 116) (Protein unc-116) DISRUPTION PHENOTYPE Conditional knockout in PVD neuron results in a complete microtubule polarity reversal in the anterior dendrite (PubMed:30254025). Conditional knockout in motor neuron reduces the number of mitochondria in the axon (PubMed:30254025). RNAi-mediated knockdown results in reduced dendritic branch formation in PVD sensory neurons (PubMed:21205795). RNAi-mediated knockdown results in an altered distribution of recycling and late endosomes (PubMed:22634595). RNAi-mediated knockdown results in defects in nuclear migration in hyp7 hypodermal precursor cells (PubMed:27697906). RNAi-mediated knockdown in a dhc-1 (js319) mutant background results in defective nuclei migrations in larval hypodermal P-cells (PubMed:27697906). {ECO:0000269|PubMed:21205795, ECO:0000269|PubMed:22634595, ECO:0000269|PubMed:27697906, ECO:0000269|PubMed:30254025}.