Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:176183
  • Symbol:met-2
  • Description:Histone-lysine N-methyltransferase met-2
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Gene ID Entry Entry Name Protein Name Type Information
176183 P34544 MET2_CAEEL Histone-lysine N-methyltransferase met-2 (EC 2.1.1.-) (EC 2.1.1.367) DISRUPTION PHENOTYPE Induced vulval precursor cells in the absence of lin-15A (PubMed:15990876). Multi-vulval phenotype is apparent when grown at 24.5 degrees Celsius in the absence of lin-61 and when grown at 20 degrees Celsius in the absence of hpl-2 or met-1 (PubMed:17634190, PubMed:21437264). Reduced lamin interaction of chromosome arms in the absence of set-25 (PubMed:22939621). Increased apoptosis and increased occurrence of the recombination checkpoint XO germ lines (PubMed:21909284). High incidence of endomitotic oocytes (PubMed:20107519). In spr-5 null mutants, accelerates the progressive sterility over generations, which is seen in spr-5 mutants with complete sterility achieved by generation 2 (PubMed:24685137). {ECO:0000269|PubMed:15990876, ECO:0000269|PubMed:17634190, ECO:0000269|PubMed:20107519, ECO:0000269|PubMed:21437264, ECO:0000269|PubMed:21909284, ECO:0000269|PubMed:22939621, ECO:0000269|PubMed:24685137}.