| 176554 | Q9NAH6 | KS6B_CAEEL | Ribosomal protein S6 kinase beta (EC 2.7.11.1) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes an increased lifespan and resistance to starvation, slower growth and a decrease in brood size (PubMed:17266680). Causes a decrease in the number of germline progenitors (PubMed:22278922). RNAi-mediated knockdown in adults causes increase in lgg-1 positive autophagic vesicles (PubMed:22560223). RNAi-mediated knockdown in a daf-2 e1370 mutant background results in daf-16-mediated up-regulation of stdh-1 reporter expression in the intestine and a synergistic increase in lifespan. RNAi-mediated knockdown in germ line, hypodermis and to a lesser extent in intestine and daf-2 e1370 mutant background causes a synergistic increase in lifespan (PubMed:24332851). {ECO:0000269|PubMed:17266680, ECO:0000269|PubMed:22278922, ECO:0000269|PubMed:22560223, ECO:0000269|PubMed:24332851}. |