| 176574 | Q9XX00 | SRBPH_CAEEL | Sterol regulatory element binding protein sbp-1 (SREBP sbp-1) [Cleaved into: Processed sterol regulatory element binding protein sbp-1] | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes early larval arrest and a pale, skinny appearance; paleness due to absence of dark, lipid-laden fat granules from the intestine (PubMed:12530969, PubMed:19936816). Decrease in body size, delayed growth, fewer eggs laid and 5-6 days after being laid, many eggs hatch inside the body (PubMed:19936816). Exposure to oleic or linoleic acid returns body size almost to normal and also increases number of eggs laid (PubMed:19936816). In normoxic conditions, reduces total fat levels, but has no effect in anoxia (PubMed:19187779). Reduces the increase in body width/length ratio caused by anoxia (PubMed:19187779). Alters fatty-acid composition, including of monomethyl branched-chain fatty acids (mmBCFAs) (PubMed:15340492). Exacerbates induction of reactive oxygen species (ROS) production and decrease in locomotion behavior caused by simulated microgravity (PubMed:32448509). Knockdown in the first generation offspring (F1) of adults fed a high-fat diet prevents lipid accumulation (PubMed:35140229). Tissue-specific knockdown in any of several different tissues abolishes elevated levels of H3K4me3 modification (PubMed:35140229). {ECO:0000269|PubMed:12530969, ECO:0000269|PubMed:15340492, ECO:0000269|PubMed:19187779, ECO:0000269|PubMed:19936816, ECO:0000269|PubMed:32448509, ECO:0000269|PubMed:35140229}. |