| 176661 | Q9XTT9 | PRS8_CAEEL | 26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit rpt-6) (Proteasome regulatory particle ATPase-like protein 6) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown at the L4 stage of larval development inhibits activity of the proteasome (PubMed:30265660). RNAi-mediated knockdown at the L4 larval stage also results in increased mortality and transcription of immune genes containing the elt-2 binding motif when exposed to Gram-negative bacteria such as P.aeruginosa (PubMed:30265660). RNAi-mediated knockdown at this stage, furthermore, prevents the recovery of P.aeruginosa infected animals treated with the antibiotic streptomycin (PubMed:30265660). {ECO:0000269|PubMed:30265660}. |