| 176758 | Q9NDC9 | LIS1_CAEEL | Lissencephaly-1 homolog (Pronuclear migration abnormal protein 1) | DISRUPTION PHENOTYPE | Defects lead to convulsions mimicking epilepsy, possibly due to altered neurotransmitter function (PubMed:15254012). RNAi-mediated knockdown results in arrest at the 50-100 cell stage, whereby egg and sperm pronuclei fails to migrate (PubMed:11685578). RNAi-mediated knockdown prevents the sperm-donated centrosome from leaving the posterior cortex in 1-cell embryos (PubMed:20599902). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown results in nuclear migration defects in hyp7 hypodermal precursor cells, but only in a small number of animals (PubMed:20005871). RNAi-mediated knockdown in a pam-1 mutant background restores anterior-posterior polarity (PubMed:20599902). {ECO:0000269|PubMed:11685578, ECO:0000269|PubMed:15254012, ECO:0000269|PubMed:16996038, ECO:0000269|PubMed:20005871, ECO:0000269|PubMed:20599902}. |