| 176808 | Q9U9Y8 | NLK_CAEEL | Serine/threonine kinase NLK (EC 2.7.11.24) (Loss of intestine protein 1) (Nemo-like kinase) | DISRUPTION PHENOTYPE | Defects in body wall muscle, endoderm development and pop-1 asymmetry (PubMed:10380924, PubMed:10391246, PubMed:9384382). RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown causes the transcription factor plp-1 to localize at much lower levels in nuclei and instead accumulate in the cytoplasm, during embryonic development. {ECO:0000269|PubMed:10380924, ECO:0000269|PubMed:10391246, ECO:0000269|PubMed:19084000, ECO:0000269|PubMed:21408209, ECO:0000269|PubMed:9384382}. |