| 176869 | G5EE01 | PTEN_CAEEL | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Abnormal dauer formation protein 18) | DISRUPTION PHENOTYPE | Mutants are viable but with a shorter lifespan. They also fail to enter dauer stage under starvation conditions and 17 percent of mutants display vulval bursting (PubMed:10209098, PubMed:10377431, PubMed:20207731). Unlike in wild-type animals, germline stem cell proliferation continues following sperm depletion and Z2/Z3 germline precursors continue to proliferate during L1 diapause (PubMed:16631584, PubMed:26552888). The number of unfertilized eggs laid after sperm depletion is also increased (PubMed:26552888). Prevents constitutive dauer entry and pharynx remodeling and restores normal brood size in a daf-2 mutant background (PubMed:10209098, PubMed:10377431). Prevents increase in lifespan in an arr-1 (ok401) mutant background or in mpz-1 RNAi-mediated knockdown animals (PubMed:20207731). Suppresses the increase in ovulation rate and mpk-1 phosphorylation in distal oocytes in a vab-1 (dx31) mutant background. Restores normal axon extension of PLM neurons in a daf-2 (e1370) mutant background (PubMed:23995781). RNAi-mediated knockdown prevents arrest at the dauer larval stage in a daf-2 or age-1 mutant background (PubMed:9885576, PubMed:10077613). In addition, suppresses increased thermotolerance and fat storage and reduces daf-16 nuclear localization in a daf-2 mutant background (PubMed:19249087). {ECO:0000269|PubMed:10077613, ECO:0000269|PubMed:10209098, ECO:0000269|PubMed:10377431, ECO:0000269|PubMed:16631584, ECO:0000269|PubMed:19249087, ECO:0000269|PubMed:20207731, ECO:0000269|PubMed:23995781, ECO:0000269|PubMed:26552888, ECO:0000269|PubMed:9885576}. |