Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:176989
  • Symbol:cmk-1
  • Description:Calcium/calmodulin-dependent protein kinase type 1
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Gene ID Entry Entry Name Protein Name Type Information
176989 Q9TXJ0 CMK1_CAEEL Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) DISRUPTION PHENOTYPE Changes in thermosensory behavior and temperature-dependent defects in AFD-specific gene expression (PubMed:10428833, PubMed:14711416, PubMed:25467978, PubMed:26725111). Decreased threshold for temperature-evoked activity in the AFD neurons. Defects in negative thermotaxis and isothermal tracking behaviors (PubMed:25467978). Defective in thermal avoidance adaptation. Aberrant thermotaxis at innocuous temperatures (PubMed:25467982). Inappropriate dauer formation under well-fed conditions. Reduced expression of growth promoting daf-7 in ASI sensory neurons (PubMed:26335407). Changes in thermosensory response of AIY neurons (PubMed:26725111). Increased transcription of glutamate receptor glr-1 (PubMed:27462879). {ECO:0000269|PubMed:10428833, ECO:0000269|PubMed:14711416, ECO:0000269|PubMed:25467978, ECO:0000269|PubMed:25467982, ECO:0000269|PubMed:26335407, ECO:0000269|PubMed:26725111, ECO:0000269|PubMed:27462879}.