| 176991 | O76360 | EGL4_CAEEL | cGMP-dependent protein kinase egl-4 (EC 2.7.11.12) (Egg-laying defective protein 4) | DISRUPTION PHENOTYPE | Increased size and extended lifespan (PubMed:11181837, PubMed:12571101, PubMed:18832350, PubMed:26434723). Defects in chemosensory behavior, egg-laying, synaptic transmission, and dauer formation (PubMed:11181837, PubMed:12571101, PubMed:18832350, PubMed:26434723). Impaired movement of adult animals in response to sensory stimuli (PubMed:10978280). Loss of adaptive behavior to long lasting exposure to attractive odorants (PubMed:20220099). Normal initial chemotaxis response during a first and short exposure to attractive odorants (PubMed:20220099). Loss of chemotaxis response to the repellent odor 2-nonanone (PubMed:23954825). Defective chemotaxis in response to diacetyl and isoamylalcohol (PubMed:26434723). High sensitivity to benzaldehyde, which is retained following pre-exposure in contrast to wild-type animals (PubMed:26434723). Increased basal cGMP levels (PubMed:24015261). {ECO:0000269|PubMed:10978280, ECO:0000269|PubMed:11181837, ECO:0000269|PubMed:12571101, ECO:0000269|PubMed:15330854, ECO:0000269|PubMed:18832350, ECO:0000269|PubMed:20220099, ECO:0000269|PubMed:24015261, ECO:0000269|PubMed:26434723}. |