Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:177391
  • Symbol:csp-2
  • Description:Putative inactive caspase subunit p14
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Gene ID Entry Entry Name Protein Name Type Information
177391 Q9TZP5 CSP2_CAEEL Putative inactive caspase B [Cleaved into: Putative inactive caspase B subunit p31; Putative inactive caspase B subunit p17; Putative inactive caspase subunit p14] DISRUPTION PHENOTYPE Survival of touch neurons and several pharyngeal cells is not affected during development. In a ced-3 n2427 or ced-3 n2427 and cps-3 n4872 mutant background, no extra pharyngeal cells caused by impaired apoptosis are produced. In a csp-3 n4872, csp-1 n4967 and ced-3 n3692 mutant background, pharyngeal cells, that are normally fated to die, survive and 16 percent of animals have still 1 or more cell corpses that are morphologically apoptotic and are internalized by engulfing cells. In addition, apoptosis of the male linker cell occurs normally. {ECO:0000269|PubMed:23505386}.