Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:177413
  • Symbol:ddi-1
  • Description:Protein DDI1 homolog 1
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Gene ID Entry Entry Name Protein Name Type Information
177413 Q17569 DDI1_CAEEL Protein DDI1 homolog 1 (EC 3.4.23.-) DISRUPTION PHENOTYPE Increased sensitivity to low doses of bortezomib which causes proteasome dysfunction. Double knockout with proteasomal subunit pbs-5 or with rpt-5 knockdown results in failed expression of the proteasomal subunit rpt-3. Double knockout with pbs-5 also results in the occasional mis-localization of the transcription factor skn-1a within gut nuclei. {ECO:0000269|PubMed:27528192}.