Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:177736
  • Symbol:nrfl-1
  • Description:Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1
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Gene ID Entry Entry Name Protein Name Type Information
177736 G5EDM4 NHRF1_CAEEL Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) DISRUPTION PHENOTYPE Viable, with no gross anatomy or growth defects observed (PubMed:22916205). Localization of aat-6 at the intestinal apical cell membrane diminishes as animals age, and eventually aat-6 becomes diffusely dispersed in the cytoplasm (PubMed:22916205). RNAi-mediated knockdown in a pept-1 (lg601) mutant background results in a reduced number of progeny (PubMed:30560135). {ECO:0000269|PubMed:22916205, ECO:0000269|PubMed:30560135}.