| 177921 | O62305 | KCC2D_CAEEL | Calcium/calmodulin-dependent protein kinase type II (CaM kinase II) (EC 2.7.11.17) (Uncoordinated protein 43) | DISRUPTION PHENOTYPE | Increased frequency of defecation, typified by a weaker repetition of the defecation motor program, an echo, 10 s after the primary motor program. Abnormal spicule protraction. Lack of tph-1 transcriptional up-regulation during learned olfactory aversion to bacteria. Reduced brood size, body length and width. Lethargic movement. A gain-of function mutation reduces locomotory activity, alters excitation of three muscle types and lengthens the period of the motor output of a behavioral clock. Both classes of mutation inhibit neurotransmitter release. {ECO:0000269|PubMed:10647014, ECO:0000269|PubMed:12221132, ECO:0000269|PubMed:17898212, ECO:0000269|PubMed:17941711, ECO:0000269|PubMed:17942636, ECO:0000269|PubMed:23325232}. |