| 177985 | Q23541 | KDM5_CAEEL | Lysine-specific demethylase rbr-2 (Histone demethylase rbr-2) (EC 1.14.11.67) (Jumonji/ARID domain-containing protein rbr-2) ([histone H3]-trimethyl-L-lysine(4) demethylase rbr-2) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown decreases lifespan in wild type worms with an intact germline (PubMed:20555324). Results in extended lifespan when egg production is inhibited by the addition of floxuridine (FUDR) or in a glp-1 mutant background which lacks a germline (PubMed:22212395, PubMed:20555324). {ECO:0000269|PubMed:20555324, ECO:0000269|PubMed:22212395}. |