Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:178201
  • Symbol:him-6
  • Description:Bloom syndrome protein homolog
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Gene ID Entry Entry Name Protein Name Type Information
178201 O18017 BLM_CAEEL RecQ-like DNA helicase blm-1 (EC 3.6.4.12) (Bloom syndrome protein homolog) (High incidence of males protein 6) (RecQ helicase homolog) DISRUPTION PHENOTYPE Reduced viability, increased rad-51 foci in the germline and an increase of meiotic crossover formation in the central region of chromosomes (PubMed:27010650). Reduced number of rmh-1 foci in the pachytene region (PubMed:27011106). In an smc-5 mutant background, defects in diakinetic chiasmata formation, compromised chromosome segregation and aberrant distribution of the condensin II subunit hcp-6 in meiosis (PubMed:27010650). {ECO:0000269|PubMed:27010650, ECO:0000269|PubMed:27011106}.