| 178217 | G5EET6 | EFA6_CAEEL | Exchange factor for Arf-6 (Arf guanine nucleotide exchange factor efa-6) (Pleckstrin homology domain-containing protein efa-6) | DISRUPTION PHENOTYPE | Abnormally long and dense microtubules at the cellular cortex of early embryonic cells and growing microtubule plus ends reside at the cortex for up to five times longer. Causes excess centrosome separation and displacement towards the cellular cortex early in mitosis and subsequently a loss of anaphase spindle-pole oscillations and increased rates of spindle elongation. The centrosome separation phenotype is dependent on the motor protein dynein. Weakly delayed nuclear envelope breakdown (PubMed:21076413). Displays mild posterior lateral microtubule (PLM) axon overshooting in development and enhanced PLM regrowth following neuronal injury acting early in regrowth (PubMed:21943602). Axons display elevated numbers of growing microtubules in the steady (uninjured) state and display impenetrant developmental overgrowth in the absence of injury (PubMed:26339988). {ECO:0000269|PubMed:21076413, ECO:0000269|PubMed:21943602, ECO:0000269|PubMed:26339988}. |