| 178458 | Q22038 | RHO1_CAEEL | Ras-like GTP-binding protein rhoA | DISRUPTION PHENOTYPE | RNAi-mediated knockdown predominantly results in embryonic arrest with surviving embryos developing elongation-defective uncoordinated kinky larvae (PubMed:24016757, PubMed:11687661). Defective ventral migration of P cells leading to defective gonad development (PubMed:11687661). Defective establishment of anterior-posterior cell polarity in one-cell embryos (PubMed:16921365). Abolished cortical contractility in early embryos (PubMed:23064028). RNAi-mediated knockdown results in disorganized myosin thick filaments in the body wall muscles of the few surviving adults, which is characterized by the formation of abnormal myosin heavy chain myo-3 aggregates, V-shaped crossing of A-bands and areas in which the myosin heavy chain is missing (PubMed:18801371). RNAi-mediated knockdown suppresses reactive oxygen species induction and longevity in the memo-1 mutant (PubMed:28085666). Double RNAi-mediated knockdown with memo-1 eliminates the resistance to oxidative stress in the memo-1 single mutant (PubMed:28085666). {ECO:0000269|PubMed:11687661, ECO:0000269|PubMed:16921365, ECO:0000269|PubMed:18801371, ECO:0000269|PubMed:23064028, ECO:0000269|PubMed:24016757, ECO:0000269|PubMed:28085666}. |