| 178740 | V6CLP5 | KETN1_CAEEL | Kettin homolog | DISRUPTION PHENOTYPE | Lethal during the larval stage of development with body elongation defects (PubMed:31411810). L1 stage larvae have severely disorganized actin filaments in the striated body wall muscle whereby actin filaments and tropomyosin assemble into thicker and fewer disorganized bundles (PubMed:31411810). Furthermore, the sarcomeric organization of actin and myo-3 is disrupted in body wall muscle cells (PubMed:31411810). RNAi-mediated knockdown reduces the brood size and results in a defective body wall muscle contractility (PubMed:16597697). RNAi-mediated knockdown results in small round actin aggregates or unusual accumulations of actin in body wall muscle in 23% of animals (PubMed:16597697). Larger actin aggregates form more frequently at the cell periphery in 94% of animals in response to tetramisole, an agonist of acetylcholine receptors (PubMed:16597697). RNAi-mediated knockdown enhances the disorganization of the actin filaments and results in larger actin aggregates in an atn-1 ok84 mutant background (PubMed:16597697). {ECO:0000269|PubMed:16597697, ECO:0000269|PubMed:31411810}. |