| 178755 | P45442 | LAG2_CAEEL | Protein lag-2 (Lethal protein 461) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown in cells of the pi uterine cell lineage results in impaired basement membrane mobility (PubMed:27661254). RNAi-mediated knockdown, on a lin-15 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate (PubMed:14960273). RNAi-mediated knockdown, when combined with knockdown of apx-1, on a dsl-1 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate; phenotype exacerbated on double mutant lin-15;dsl-1 background (PubMed:14960273). RNAi-mediated knockdown, on a lin-12 mutant background, induces the presence of 1-2 extra mesodermal lineage (M lineage)-derived coelomocytes and the concomitant loss of sex myoblasts on the ventral side of the animal (PubMed:18036582). On an apx-1 mutant background, RNAi-mediated knockdown causes germ cells to display nuclear morphology consistent with meiotic prophase or gametogenesis in adult hermaphrodites (PubMed:19502484). {ECO:0000269|PubMed:14960273, ECO:0000269|PubMed:18036582, ECO:0000269|PubMed:19502484, ECO:0000269|PubMed:27661254}. |