| 178759 | P41990 | APX1_CAEEL | Anterior pharynx in excess protein 1 | DISRUPTION PHENOTYPE | RNAi-mediated knockdown in the L1 larval stage causes an endomitotic oocyte phenotype; effect not seen if knockdown is targeted to germline, rather than somatic cells (PubMed:29371032). RNAi-mediated knockdown alters ovulation (PubMed:29371032). Spermatheca calcium flux is altered by RNAi-mediated knockdown (PubMed:29371032). RNAi-mediated knockdown, on a lag-2 mutant background, induces the presence of 1-2 extra mesodermal lineage (M lineage)-derived coelomocytes (PubMed:18036582). RNAi-mediated knockdown on a lin-15 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate (PubMed:14960273). On a lag-2 mutant background, RNAi-mediated knockdown causes germ cells to display nuclear morphology consistent with meiotic prophase or gametogenesis in adult hermaphrodites (PubMed:19502484). RNAi-mediated knockdown, when combined with RNAi-mediated knockdown of lag-2, on a dsl-1 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate; phenotype exacerbated on double mutant lin-15;dsl-1 background (PubMed:14960273). {ECO:0000269|PubMed:14960273, ECO:0000269|PubMed:18036582, ECO:0000269|PubMed:19502484, ECO:0000269|PubMed:29371032}. |