| 178768 | G5ECQ2 | FRIZ2_CAEEL | Frizzled-2 | DISRUPTION PHENOTYPE | Displaced anterior nerve ring and neuronal cell migration defects including irregular localization of canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right (but not the left) Q neuroblast (QR) and its descendants (PubMed:16109397, PubMed:9851916). Axon growth and guidance defects whereby some HSN, male CP neurons and CAN extend ectopic axons or branches, and furthermore some HSN irregularly route towards the ventral midline of the body (PubMed:16109397). Disorganized cells of the anterior ganglion which are normally compacted together when they form the head ganglion in wild-type animals (PubMed:16109397). Double knockout with mom-5 or cwn-2 results in enhanced CAN migration defects (PubMed:16109397). Double knockout with Wnt ligands cwn-1, cwn-2, egl-20 or frizzled protein mom-5 rescues the ALM migration defects in the single cfz-2 knockout (PubMed:16109397). Triple knockout with cwn-1 and cwn-2 results in enhanced neuronal cell migratory defects (PubMed:16109397). {ECO:0000269|PubMed:16109397, ECO:0000269|PubMed:9851916}. |