| 179013 | O01583 | MRCK_CAEEL | Serine/threonine-protein kinase mrck-1 (EC 2.7.11.1) (Myotonic dystrophy kinase-related CDC42-binding kinase homolog) | DISRUPTION PHENOTYPE | Normal adult development, but progeny arrest at either the L1 stage or during embryogenesis (PubMed:19675126). RNAi-mediated knockdown causes excretory canal truncation, abnormal lumen and cyst formation. In addition, causes a reduced distribution of Golgi and ER components along the excretory canal length and a decrease in cdc-42 activation (PubMed:25743393). {ECO:0000269|PubMed:19675126, ECO:0000269|PubMed:25743393}. |