| 179274 | H2L099 | GCK1_CAEEL | Germinal center kinase 1 (EC 2.7.11.1) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes sterility resulting from several defects in oogenesis. Proximal ends of the gonads are filled with small germ cells and have a decrease in the number of nuclei in all stages of oogenesis especially at the pachytene stage where there is 60 percent less nuclei. In addition, animals lack a discernible rachis which is a tube-like formation of anucleate cytoplasm between pachytene nuclei, no clear transition into progression from pachytene to diplotene stage and a failure to progress from diplotene into diakinesis. Increased germline cell apoptosis (PubMed:19826475). RNAi-mediated knockdown causes truncated excretory canals associated with the formation of cysts, a reduced distribution of Golgi and ER components along the excretory canals and a decrease in cdc-42 activation (PubMed:25743393). {ECO:0000269|PubMed:19826475, ECO:0000269|PubMed:25743393}. |