| 179300 | Q8MNV0 | SPAST_CAEEL | Spastin homolog (EC 5.6.1.1) | DISRUPTION PHENOTYPE | Slow growth, reduced brood size, abnormal oogenesis and multiple vulvae (PubMed:17531954). Progressive locomotor defects, which is rescued following exposure to the drugs guanabenz, salubrinal, phenazine, or methylene blue (PubMed:26744324). Lifespan is prolonged following exposure to the drugs guanabenz, salubrinal or methylene blue, but not phenazine (PubMed:26744324). Increases numbers of centrosomal microtubules in early embryos (PubMed:17531954). Reduced neutral lipid levels in intestinal cells (PubMed:25875445). RNAi-mediated knockdown results in paralysis due to an increase in the endoplasmic reticulum stress response, which is rescued following exposure to the drugs methylene blue, guanabenz, salubrinal, or phenazine (PubMed:26744324). {ECO:0000269|PubMed:17531954, ECO:0000269|PubMed:25875445, ECO:0000269|PubMed:26744324}. |