| 179749 | Q19555 | SCC3_CAEEL | Cohesin subunit scc-3 | DISRUPTION PHENOTYPE | RNAi-mediated knockdown results in embryonic lethality (PubMed:14560015, PubMed:12827206, PubMed:12808038, PubMed:16802858). RNAi-mediated knockdown from early in larval development results in sterile, uncoordinated (Unc), and protruding vulva phenotypes, in abnormal embryonic cell nuclei morphology and in defects in the mitotic and meiotic cells of gonads (PubMed:14499625, PubMed:14560015). RNAi-mediated knockdown results in somatic gonad cell division defects with a reduced number of pi uterine cells at the early- to mid-L4 larval stage (PubMed:14560015). RNAi-mediated knockdown results in chromosome segregation defects in early embryos with lagging chromosomes at the anaphase phase of mitosis (PubMed:14499625, PubMed:12808038, PubMed:16802858). RNAi-mediated knockdown results in defective homologous alignment of chromosomes and chromosome cohesion in meiosis (PubMed:14499625). {ECO:0000269|PubMed:12808038, ECO:0000269|PubMed:12827206, ECO:0000269|PubMed:14499625, ECO:0000269|PubMed:14560015, ECO:0000269|PubMed:16802858}. |