| 179912 | Q9TW45 | PAR1_CAEEL | Serine/threonine-protein kinase par-1 (EC 2.7.11.1) | DISRUPTION PHENOTYPE | Maternal effect lethality. Blastomeres cleave synchronously until the fourth or fifth round, when synchrony breaks down. Cells also fail to segregate P granules. Terminal stage embryos fail to produce intestinal cells. Disruption post-hatching results in a protruding vulva, the two mirror-symmetric halves of the vulva fail to join into a single, coherent organ. {ECO:0000269|PubMed:12490197, ECO:0000269|PubMed:3345562}. |