Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:180398
  • Symbol:dve-1
  • Description:Homeobox domain-containing protein
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Gene ID Entry Entry Name Protein Name Type Information
180398 Q86MI0 DVE1_CAEEL Homeobox protein dve-1 (Defective proventriculus homolog protein) DISRUPTION PHENOTYPE RNAi-mediated knockdown inhibits expression of hsp-60 when adults are exposed to conditions causing mitochondrial unfolded protein stress (PubMed:17925224). Causes abnormal mitochondrial morphology (PubMed:17925224). Drastically reduces the protein level of hda-1, possibly via ubiquitin-mediated degradation (PubMed:32934238). Under conditions of mitochondrial stress, partially suppresses nuclear accumulation of lin-40 and lin-53 (PubMed:32789178). {ECO:0000269|PubMed:17925224, ECO:0000269|PubMed:32789178, ECO:0000269|PubMed:32934238}.