| 180549 | Q10572 | FOX1_CAEEL | Sex determination protein fox-1 (Feminizing locus on X protein 1) | DISRUPTION PHENOTYPE | Males and hermaphrodites are viable and there is no change in brood size (PubMed:9217163, PubMed:17720939, PubMed:33372658). In a sex-1(y263) mutant background or a sex-1 RNAi mutant background, males are viable, but hermaphrodites have highly reduced viability due to failure of the dosage compensation complex to assemble on X chromosomes, and the surviving animals show a reduction in brood size (PubMed:17720939, PubMed:16139225, PubMed:33372658). RNAi-mediated knockdown results in a 63% reduction in the number of eggs produced (PubMed:11303786). RNAi-mediated knockdown together with sex-1 results in hermaphrodite embryonic lethality (PubMed:21471153). This hermaphrodite-specific lethality is suppressed in a sea-2 bp283 mutant or sea-1 gk799 mutant background (PubMed:21471153). {ECO:0000269|PubMed:11303786, ECO:0000269|PubMed:16139225, ECO:0000269|PubMed:17720939, ECO:0000269|PubMed:21471153, ECO:0000269|PubMed:33372658, ECO:0000269|PubMed:9217163}. |