| 180695 | Q8MQ70 | HIPK_CAEEL | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) | DISRUPTION PHENOTYPE | Enhanced sensitivity to heat and oxidative stress with reduced survival under both conditions (PubMed:26791749, PubMed:29036198). Following exposure to gamma irradiation, no effect on DNA damage response in the germline but significantly reduced embryonic survival (PubMed:26791749). Significantly reduced lifespan with a more rapid decline in body movement and pharyngeal pumping, indicative of accelerated aging (PubMed:26791749, PubMed:29036198). Premature accumulation of polyglutamine aggregates and increased polyglutamine-associated paralysis at day 8 of adulthood (PubMed:29036198). RNAi-mediated knockdown results in small and underdeveloped germlines with a reduction in the number of cells in G2/M stages (PubMed:23904186). RNAi-mediated knockdown from the L1 larval stage onwards results in shortened lifespan while RNAi-mediated knockdown initiated at the L4 larval stage decreases lifespan to a smaller but significant extent (PubMed:29036198, PubMed:36173858). RNAi-mediated knockdown in the intestine, hypodermis or neurons reduces lifespan while RNAi-mediated knockdown in muscle cells does not (PubMed:29036198). {ECO:0000269|PubMed:23904186, ECO:0000269|PubMed:26791749, ECO:0000269|PubMed:29036198}. |