| 180873 | Q17850 | PK1_CAEEL | Serine/threonine-protein kinase pak-1 (EC 2.7.11.1) (CePAK) (p21-activated kinase 1) (PAK1) | DISRUPTION PHENOTYPE | In pak-1 and pak-2 double mutants, defects in embryogenesis and L1 stage lethality. The few animals reaching adulthood have normal ventral cord commissural motoneuron axonal guidance and are relatively coordinated. In max-2 and pak-1 double mutants, DD and DC motoneuron axons fail to reach the dorsal cord (PubMed:17050621). Animals are also uncoordinated, defective in egg laying and in distal tip cell (DTC) migration, guidance and morphology, and exhibit ventral enclosure defects (PubMed:17050621, PubMed:19023419). {ECO:0000269|PubMed:17050621, ECO:0000269|PubMed:19023419}. |