| 180942 | G5EG44 | MDL1_CAEEL | Mad-like protein 1 | DISRUPTION PHENOTYPE | RNAi-mediated knockdown increases lifespan, which is abolished on an mxl-2 or mml-1 mutant background, or by simultaneous RNAi-mediated knockdown of daf-16 or pha-4 (PubMed:24699255). RNAi-mediated knockdown causes delayed onset of polyglutamine-mediated paralysis (PubMed:24699255). RNAi-mediated knockdown reduces spore levels of the microsporidian pathogen N.parisii during infection, further reduced on an mxl-2 mutant background (PubMed:27402359). {ECO:0000269|PubMed:24699255, ECO:0000269|PubMed:27402359}. |