| 181004 | Q21307 | MEK1_CAEEL | Dual specificity mitogen-activated protein kinase kinase mek-1 (EC 2.7.12.2) | DISRUPTION PHENOTYPE | Loss of kgb-1 activation (PubMed:15116070, PubMed:20008556). Hypersensitivity to high concentrations of copper (> 50 microM) and cadmium (>5 microM) and to food starvation which is characterized by a failure for most animals to reach adulthood. The few surviving adults appear starved and are defective in egg laying and are infertile (PubMed:11013217, PubMed:15116070). In addition, have moderate susceptibility to pathogenic bacteria infection characterized by a shorter lifespan and a substantial decrease in pmk-1 phosphorylation (PubMed:15256594). In absence of stress, animals have no obvious phenotype (PubMed:11013217, PubMed:15116070). {ECO:0000269|PubMed:11013217, ECO:0000269|PubMed:15116070, ECO:0000269|PubMed:15256594, ECO:0000269|PubMed:20008556}. |