| 181043 | G5EDF7 | SEK1_CAEEL | Dual specificity mitogen-activated protein kinase kinase sek-1 (MAP kinase kinase sek-1) (EC 2.7.12.2) | DISRUPTION PHENOTYPE | Upon infection by P.aeruginosa and E.faecalis, RNAi-mediated knockdown results in a reduced up-regulation of gst-4 and gcs-1 expression (PubMed:22216003). Causes a severe reduction in rnt-1 accumulation in the intestine during oxidative stress mediated by paraquat (PubMed:22308034). RNAi-mediated knockdown in a ced-1 mutant background causes a moderate reduction in germline cell apoptosis during oogenesis in response to oxidative and heat shock stresses. The phenotype is more severe and also affects the response to osmotic stress in a mek-1 and ced-1 mutant background (PubMed:16729024). {ECO:0000269|PubMed:16729024, ECO:0000269|PubMed:22216003, ECO:0000269|PubMed:22308034}. |