| 181067 | Q21286 | CATP5_CAEEL | Cation-transporting ATPase catp-5 (EC 7.2.2.-) | DISRUPTION PHENOTYPE | Disrupts the polyamine uptake and/or transport of the polyamine conjugate Ant-4,4 and norspermidine, a toxic structural analog of the polyamine spermidine. Intracellular levels of the natural polyamines spermidine and putrescine are as wild-type. Double knockout with either odc-1 or smd-1 (two enzymes involved in polyamine synthesis) results in a reduced brood size, delayed postembryonic development and reduced intracellular levels of spermidine. Double knockout with odc-1 results in reduced levels of the polyamine putrescine, while double knockout with smd-1 results in increased accumulation of putrescine. {ECO:0000269|PubMed:19762559}. |