Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:181248
  • Symbol:mig-15
  • Description:Serine/threonine-protein kinase mig-15
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Gene ID Entry Entry Name Protein Name Type Information
181248 Q23356 MIG15_CAEEL Serine/threonine-protein kinase mig-15 (EC 2.7.11.1) (Abnormal cell migration protein 15) DISRUPTION PHENOTYPE Mutants exhibit premature branching of commissures (PubMed:11967148). RNAi-mediated knockdown results in gonad distal tip cell (DTC) migration defects whereby DTCs do not migrate to the midbody of the hermaphrodite and as a consequence this leads to abnormal gonadal arm formation during gonad morphogenesis (PubMed:22732572). Double knockdown with mig-38 results in enhanced gonad DTC migration defects (PubMed:22732572). {ECO:0000269|PubMed:11967148, ECO:0000269|PubMed:22732572}.