| 181251 | G5EDS1 | VAB3_CAEEL | Paired box protein 6 homolog (Homeobox and paired domain-containing protein vab-3) (Protein male abnormal 18) (Variable abnormal morphology protein 3) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes defects in gonadal distal tip cell migration (PubMed:17606640). RNAi-mediated knockdown reduces expression of the integrin alpha pat-2 in gonadal DTCs in about 70% of individuals and in 90% on a vab-3 mutant background (PubMed:17606640). RNAi-mediated knockdown increases expression of the integrin alpha ina-1 in gonadal DTCs in hermaphrodites (PubMed:17606640). RNAi-mediated knockdown induces generation of additional dopaminergic neurons (PubMed:21079745). BAG sensory neuron-specific RNAi-mediated knockdown reduces expression of receptor-type guanylyl cyclase gcy-9 (PubMed:30890567). {ECO:0000269|PubMed:17606640, ECO:0000269|PubMed:21079745, ECO:0000269|PubMed:30890567}. |