| 181341 | G5EBL3 | SDC2_CAEEL | Sex determination and dosage compensation protein sdc-2 | DISRUPTION PHENOTYPE | Results in high lethality of hermaphrodites (XX) and in masculinization of surviving XX animals (PubMed:2759421). Disrupts the X-chromosome specific localization of sdc-3, dpy-21, dpy-26, dpy-27 and mix-1 (PubMed:9056777, PubMed:8939869, PubMed:8939870, PubMed:9458050, PubMed:14660541). RNAi-mediated knockdown results in 86% viability of hermaphrodites (PubMed:23666922). RNAi-mediated knockdown results in increased sensitivity to the heavy metal arsenite (PubMed:25204677). RNAi-mediated knockdown reduces the viability of hermaphrodites to 19% in a double xol-1(y9) and sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 11% in a triple sea-1(y356), xol-1(y9) and sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 42% in a triple sea-2(y407), xol-1(y9) sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 51% in a quadruple sea-1(y356), sea-2(y407), xol-1(y9) sex-1(y263) mutant background (PubMed:23666922). {ECO:0000269|PubMed:14660541, ECO:0000269|PubMed:23666922, ECO:0000269|PubMed:25204677, ECO:0000269|PubMed:2759421, ECO:0000269|PubMed:8939869, ECO:0000269|PubMed:8939870, ECO:0000269|PubMed:9056777, ECO:0000269|PubMed:9458050}. |